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Changes of heart rate variability during exercise

We use recent developments in heart rate dynamic estimation to detrend athlete's heart rate measured during effort tests and study how heart rate variability (HRV) changes during exercise, in a sample of 18 young athletes. RR interval standard …

Op0231 Comparative Effectiveness of Jak-Inhibitors, Tnf-Inhibitors, Abatacept and Il-6 Inhibitors in an International Collaboration of Registers of Rheumatoid Arthritis Patients (the “Jak-Pot” Study)

Background: In many countries, JAK-inhibitors (JAKi) have only recently been approved as treatment for patients with rheumatoid arthritis (RA).Objectives: To evaluate the effectiveness of JAKi compared to bDMARDs in RA patients in the real-world …

Sat0005 Detection of Highly Expanded T Cell Clones in the Peripheral Blood of at Risk Individuals for Rheumatoid Arthritis Before the Clinical Onset of the Disease

**Background**: Rheumatoid arthritis (RA) is an autoimmune disease with unknown etiopathogenesis. Systemic autoimmunity precedes clinical disease onset, and current evidence suggests that the immune onset of RA takes place outside of the joints …

Sat0587 the Art of Imputing Missing Data of Disease and Function Activity in Rheumatoid Arthritisregistries

**Background**: Large observational studies become more common in rheumatoid arthritis (RA). Disease registers [1] allow to analyse the effectiveness and safety of RA treatments in real-world populations, but observational studies suffer from missing …

Sat0588 Comparative Effectiveness Research in Observational Settings: Evaluating Two New Methods to Analyse Response Rates

**Background**: Researchers typically report the proportion of patients reaching a defined clinical threshold (e.g. EULAR response, low disease activity (LDA) rates) after a set time. Comparing response rates (%rr) in observational settings is …

Multi-Wavelength Laser Control of High-Voltage Discharges: From the Laboratory to Säntis Mountain

We review recent results on multi-wavelength multipulse schemes to control high-voltage discharges with ultrashort pulses, and discuss their implications on lightning control at atmospheric scale.

FRI0110 The impact of seropositivity on the effectiveness of abatacept versus tnf inhibitors in rheumatoid arthritis. real life data from several european registries (THE PAN-ABA STUDY)

**Background** Rheumatoid factor (RF) and anti-citrullinated protein antibodies (ACPA) are used as diagnostic tools, but may also be used as prognostic factors, as these biomarkers have been associated with better clinical responses to some biologic …